Last couple times I was at Clark Brothers I saw a woman there that was shooting a .500 mag.
She was having a lot of fun and could actually handle it even though she was in her 60's.
Here is a vid of a .500 to show the kind of recoil we are talking about.
The recoil is actually less the shorter the barrel is. You can clearly see a lot of propellent igniting after it exits the barrel.